The natural extract contains substances with various biological activities and has been used in many fields such as medicine, agriculture, and food science. A special focus has been on berry species because berry crops are well-recognized as a valuable source of bioactive chemicals that can be employed for health-promoting activities.
Aronia melanocarpa, also known as black chokeberry, is widely consumed as a food and also used for various purposes such as natural food colorants and herbal medicine because it is rich in anthocyanins, proanthocyanidins, flavonols, etc., followed by quercetin, quercetin glycosides and epicatechin, etc.
Aging is associated with changes in collagen fiber content in the skin, primarily reduced type I collagen synthesis, which contributes to deep wrinkles and the sagging of skin[1].Skin aging is also associated with increased expression of degradative enzymes such as matrix metalloproteinase (MMP). It can break down collagen and elastin fibers, resulting in reduced collagen deposition[2]. Korean scholars explored the effects of Aronia berry extract on skin cell growth and collagen synthesis through biological experiments in their article[3].
Aronia Extract Moderately Increases the Growth of Human Skin Cells
The normal human keratinocytes (HaCaT cells) and the neonatal human dermal fibroblasts (HDFn cells) were exposed to various concentrations of the Aronia extract, and cell viability was assessed.And the results suggest that Aronia extract does not exhibit cytotoxicity; rather, it promotes the growth of human skin cells.
Aronia Extract Promote Collagen Synthesis In Human Dermal Fibroblasts
Experiments conducted by Korean scholars have shown that Aronia extracts increased COL1A1 expression in HDFn cells (Figure 2(a)), demonstrating that Aronia extract regulates COL1A1 in HDFn cells. Aronia extract treatment upregulated the level of COL1A1 promoter activity and regulates COL1A1 mRNA level not by mRNA degradation but by transcriptional activation.
Aronia Extract downregulate MMPs
To clarify whether Aronia extract regulates the expression of MMPs, the scholars measured the mRNA levels of MMP1 and MMP3. The results showed that the expression of MMP1 and MMP3 decreased following treatment with Aronia extract and Aronia extract plays a role at the same time for type I collagen and MMP-1, which is known to degrade it.
Binmei Biotechnology Aronia berry extract powder and liquid
Aronia berry extracts are allowed to be used in most countries, including Europe, the United States, Japan, and China, etc. BINMEI uses its top-quality aronia berry to produce its spirulina extract through a strict quality system, BINMEI’s aronia berry extract is guaranteed to be world-class. Our Aronia berry extract is FSSC 22000-certified, which ensures we manage our food safety responsibilities effectively. We’re also ensured by many certifications including Kosher, Halal.
1.Quan T., Qin Z., Shao Y., Xu Y., Voorhees J. J., Fisher G. J. Retinoids suppress cysteine-rich protein 61 (CCN1), a negative regulator of collagen homeostasis, in skin equivalent cultures and aged human skin in vivo. Experimental Dermatology . 2011;20(7):572–576. doi: 10.1111/j.1600-0625.2011.01278.x.
2.Van Doren S. R. Matrix metalloproteinase interactions with collagen and elastin. Matrix Biology . 2015;44-46:224–231. doi: 10.1016/j.matbio.2015.01.005.
3.Hwa-Rim Lee, Hye Guk Ryu, Yunji Lee, Ju An Park, Seongju Kim, Chang Eon Lee, Sungjune Jung,corresponding author and Kyung-Ha Le. Effect of Aronia Extract on Collagen Synthesis in Human Skin Cell and Dermal Equivalent. 2022 Aug 8:2022:4392256. doi: 10.1155/2022/4392256. eCollection 2022.
